Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering.
Biopolymers
; 114(1): e23527, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36444710
ABSTRACT
With an ageing world population and ~20% of adults in Europe being affected by bone diseases, there is an urgent need to develop advanced regenerative approaches and biomaterials capable to facilitate tissue regeneration while providing an adequate microenvironment for cells to thrive. As the main components of bone are collagen and apatite mineral, scientists in the tissue engineering field have attempted in combining these materials by using different biomimetic approaches to favour bone repair. Still, an ideal bone analogue capable of mimicking the distinct properties (i.e., mechanical properties, degradation rate, porosity, etc.) of cancellous bone is to be developed. This review seeks to sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Materiais Biomiméticos
Idioma:
En
Revista:
Biopolymers
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido