The Protein Unfolded State: One, No One and One Hundred Thousand.
J Am Chem Soc
; 144(49): 22352-22357, 2022 12 14.
Article
em En
| MEDLINE
| ID: mdl-36450361
ABSTRACT
Many in vitro studies, in which proteins have been unfolded by the action of a variety of physical or chemical agents, have led to the definition of a folded versus an unfolded state and to the question of what is the nature of the unfolded state. The unstructured nature of this state could suggest that "the" unfolded state is a unique entity which holds true for all kinds of unfolding processes. This assumption has to be questioned because the unfolding processes under different stress conditions are dictated by entirely different mechanisms. As a consequence, it can be easily understood that the final state, generically referred to as "the unfolded state", can be completely different for each of the unfolding processes. The present review examines recent data on the characteristics of the unfolded states emerging from experiments under different conditions, focusing specific attention to the level of compaction of the unfolded species.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Dobramento de Proteína
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Reino Unido