Risk of hospitalization in a sample of COVID-19 patients with and without chronic obstructive pulmonary disease.
Respir Med
; 206: 107064, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36459955
ABSTRACT
BACKGROUND AND OBJECTIVE:
Patients with chronic obstructive pulmonary disease (COPD) may have worse coronavirus disease-2019 (COVID-19)-related outcomes. We compared COVID-19 hospitalization risk in patients with and without COPD.METHODS:
This retrospective cohort study included patients ≥40 years, SARS-CoV-2 positive, and with Kaiser Permanente Northern California membership ≥1 year before COVID-19 diagnosis (electronic health records and claims data). COVID-19-related hospitalization risk was assessed by sequentially adjusted logistic regression models and stratified by disease severity. Secondary outcome was death/hospice referral after COVID-19. RESULTS ANDDISCUSSION:
Of 19,558 COVID-19 patients, 697 (3.6%) had COPD. Compared with patients without COPD, COPD patients were older (median age 69 vs 53 years); had higher Elixhauser Comorbidity Index (5 vs 0) and more median baseline outpatient (8 vs 4), emergency department (2 vs 1), and inpatient (2 vs 1) encounters. Unadjusted analyses showed increased odds of hospitalization with COPD (odds ratio [OR] 3.93; 95% confidence interval [CI] 3.40-4.60). After full risk adjustment, there were no differences in odds of hospitalization (OR 1.14, 95% CI 0.93-1.40) or death/hospice referral (OR 0.96, 95% CI 0.72-1.27) between patients with and without COPD. Primary/secondary outcomes did not differ by COPD severity, except for higher odds of hospitalization in COPD patients requiring supplemental oxygen versus those without COPD (OR 1.84, 95% CI 1.02-3.33).CONCLUSIONS:
Except for hospitalization among patients using supplemental oxygen, no differences in odds of hospitalization or death/hospice referral were observed in the COVID-19 patient sample depending on whether they had COPD.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença Pulmonar Obstrutiva Crônica
/
COVID-19
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Aged
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Humans
Idioma:
En
Revista:
Respir Med
Ano de publicação:
2023
Tipo de documento:
Article