The Role of Maternal Preconception Adiposity in Human Offspring Sex and Sex Ratio.
Am J Epidemiol
; 192(4): 587-599, 2023 04 06.
Article
em En
| MEDLINE
| ID: mdl-36460625
ABSTRACT
We evaluated relationships between preconception adiposity and human offspring sex and sex ratio. Using data from a prospective preconception cohort nested within a randomized controlled trial based at 4 US clinical sites (2006-2012), we used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for malefemale sex ratio, and log-identity regression to estimate risk differences (RDs) and 95% CIs for male and female livebirth according to preconception adiposity measures. Inverse-probability weights accounted for potential selection bias. Among 603 women attempting pregnancy, there were meaningful reductions in sex ratio for the highest category of each adiposity measure. The lowest sex ratios were observed for obesity (body mass index of ≥30, calculated as weight (kg)/height (m)2, OR = 0.48, 95% CI 0.26, 0.88) relative to normal body mass index, and the top tertiles (tertile 3) of serum leptin (OR = 0.50, 95% CI 0.32, 0.80) and skinfold measurements (OR = 0.50, 95% CI 0.32, 0.79) relative to the lowest tertiles. Reductions were driven by 11-15 fewer male livebirths per 100 women (for obesity, RD = -15, 95% CI -23, -6.7; for leptin tertile 3, RD = -11, 95% CI -20, -3.2; and for skinfolds tertile 3, RD = -11, 95% CI -19, -3.3). We found that relationships between preconception adiposity measures and reduced sex ratio were driven by a reduction in male births.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Adiposidade
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Obesidade Materna
Tipo de estudo:
Clinical_trials
Limite:
Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Am J Epidemiol
Ano de publicação:
2023
Tipo de documento:
Article