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Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility.
Woodhouse, Rachel M; Frolows, Natalya; Wang, Guoqiang; Hawdon, Azelle; Wong, Edmund Heng Kin; Dansereau, Linda C; Su, Yingying; Adair, Liam D; New, Elizabeth J; Philp, Ashleigh M; Tan, Wei Kang; Philp, Andrew; Ashe, Alyson.
Afiliação
  • Woodhouse RM; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
  • Frolows N; Division of Genome Science and Cancer, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia.
  • Wang G; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
  • Hawdon A; CSIRO Health and Biosecurity, Sydney, NSW 2113, Australia.
  • Wong EHK; Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
  • Dansereau LC; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
  • Su Y; Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
  • Adair LD; The University of Sydney, School of Life and Environmental Sciences, Sydney, NSW 2006, Australia.
  • New EJ; Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
  • Philp AM; St Vincent's Clinical School, UNSW Medicine, University of NSW, Sydney, NSW 2010, Australia.
  • Tan WK; Sydney Microscopy and Microanalysis, The University of Sydney, Sydney, NSW 2006, Australia.
  • Philp A; The University of Sydney, School of Chemistry, Sydney, NSW 2006, Australia.
  • Ashe A; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Sydney, Sydney, NSW 2006, Australia.
iScience ; 25(12): 105573, 2022 Dec 22.
Article em En | MEDLINE | ID: mdl-36465130
ABSTRACT
Mitochondrial health is crucial to sperm quality and male fertility, but the precise role of mitochondria in sperm function remains unclear. SDHA is a component of the succinate dehydrogenase (SDH) complex and plays a critical role in mitochondria. In humans, SDH activity is positively correlated with sperm quality, and mutations in SDHA are associated with Leigh Syndrome. Here we report that the C. elegans SDHA orthologue SDHA-2 is essential for male fertility sdha-2 mutants produce dramatically fewer offspring due to defective sperm activation and motility, have hyperfused sperm mitochondria, and disrupted redox balance. Similar sperm motility defects in sdha-1 and icl-1 mutant animals suggest an imbalance in metabolites may underlie the fertility defect. Our results demonstrate a role for SDHA-2 in sperm motility and male reproductive health and establish an animal model of SDH deficiency-associated infertility.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: IScience Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Austrália