Using Digestion by IdeS Protease to Improve Quantification of Degradants in Monoclonal Antibodies by Non-Reducing Capillary Gel Electrophoresis.

McClain, Andrew; Zhang, Yiting; Yin, Yan; Wang, Qi; Hwang, Lih-Yueh; Gu, Yan; Beckman, Jeff; Ludwig, Richard

McClain, Andrew; Zhang, Yiting; Yin, Yan; Wang, Qi; Hwang, Lih-Yueh; Gu, Yan; Beckman, Jeff; Ludwig, Richard.

Afiliação

McClain A; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.
Zhang Y; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.
Yin Y; Bristol Myers Squibb, 200 Cambridgepark Drive, Cambridge, Massachusetts02140, United States.
Wang Q; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.
Hwang LY; Bristol Myers Squibb, 556 Morris Ave, Summit, New Jersey07901, United States.
Gu Y; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.
Beckman J; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.
Ludwig R; Bristol Myers Squibb, 38 Jackson Rd, Devens, Massachusetts01434, United States.

Anal Chem ; 94(50): 17388-17395, 2022 12 20.

Article em En | MEDLINE | ID: mdl-36472948

Assuntos

Anticorpos Monoclonais; Peptídeo Hidrolases; Humanos; Anticorpos Monoclonais/análise; Eletroforese Capilar/métodos; Imunossupressores; Endopeptidases; Digestão

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Anticorpos Monoclonais Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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