The first Chinese National Union of Real-world Gynaecological Oncology Research and Patient Management Platform: A retrospective study.
BJOG
; 129 Suppl 2: 60-69, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36485066
ABSTRACT
OBJECTIVE:
To produce high-quality, real-world evidence for oncologists by collating scattered gynaecologic oncology (GO) medical records in China.DESIGN:
Retrospective study.SETTING:
The National Union of Real-world Gynaecological Oncology Research and Patient Management Platform (NUWA platform). SAMPLE Patient-centred data pool.METHODS:
The NUWA platform integrated inpatient/outpatient clinical, gene and follow-up data. Data of 11 456 patients with ovarian cancer (OC) were collected and processed using 91 345 electronic medical records. Structured and unstructured data were de-identified and re-collated into a patient-centred data pool using a predefined GO data model by technology-aided abstraction. MAIN OUTCOMEMEASURES:
Recent treatment pattern shifts towards precision medicine for OC in China.RESULTS:
Thirteen first-tier hospitals across China participated in the NUWA platform up to 7 December 2021. In total, 3504 (30.59%) patients were followed up by a stand-alone patient management centre. The percentage of patients undergoing breast cancer gene (BRCA) mutation tests increased by approximately six-fold between 2017 and 2018. A similar trend was observed in the administration rate of poly(ADP-ribose) polymerase inhibitors as first-line treatment and second-line treatment after September 2018, when olaparib was approved for clinical use in China.CONCLUSION:
The NUWA platform has great potential to facilitate clinical studies and support drug development, regulatory reviews and healthcare decision-making.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
População do Leste Asiático
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
BJOG
Assunto da revista:
GINECOLOGIA
/
OBSTETRICIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China