The second-generation tyrosine kinase inhibitor afatinib inhibits IL-1ß secretion via blocking assembly of NLRP3 inflammasome independent of epidermal growth factor receptor signaling in macrophage.

Xie, Shujun; Liang, Jiafeng; Zhao, Yanyan; Zhang, Jingjing; Chen, Xueqin; Jiang, Hong; Zhang, Zhen; Ma, Shenglin; Zhang, Shirong

Xie, Shujun; Liang, Jiafeng; Zhao, Yanyan; Zhang, Jingjing; Chen, Xueqin; Jiang, Hong; Zhang, Zhen; Ma, Shenglin; Zhang, Shirong.

Afiliação

Xie S; Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer center, Zhejiang University, Hangzhou 310006, China; Departme
Liang J; Department of Radiotherapy, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Zhao Y; Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer center, Zhejiang University, Hangzhou 310006, China.
Zhang J; Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer center, Zhejiang University, Hangzhou 310006, China.
Chen X; Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310006, China.
Jiang H; Department of Cardiothoracic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine; Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Hangzhou 310006, China.
Zhang Z; Department of Orthopedic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Ma S; Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310006, China; Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhe
Zhang S; Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Cancer Center, Zhejiang University, Hangzhou 310006, China; Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhe

Mol Immunol ; 153: 135-145, 2023 01.

Article em En | MEDLINE | ID: mdl-36495818

Assuntos

Afatinib; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Afatinib/farmacologia; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Receptores ErbB; Inflamassomos/metabolismo; Neoplasias Pulmonares/patologia; Macrófagos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; /farmacologia

Palavras-chave

EGFR; Inflammasome; NLRP3; TKI

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Afatinib / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Mol Immunol Ano de publicação: 2023 Tipo de documento: Article

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