[Autoimmune encephalitis-An update]. / Autoimmunenzephalitis ein Update.
Nervenarzt
; 94(6): 525-537, 2023 Jun.
Article
em De
| MEDLINE
| ID: mdl-36515716
ABSTRACT
Detection of autoantibodies against neurons and glia cells has brought about the early and specific diagnosis of autoimmune encephalitis in patients with variable neurological and psychiatric symptoms. Growing knowledge not only resulted in profound changes in treatment algorithms including immunotherapy but also in the understanding of disease mechanisms and etiological factors. The still increasing numbers of new autoantibodies calls for continuous updates on the state of the art in antibody diagnostics, frequencies of associated tumors and the clinical spectrum linked to each antibody, which can range from mood changes, cognitive impairment and epileptic seizures to abnormal movements, autonomic dysfunction and impaired levels of consciousness. This article summarizes the recent developments in the predominant clinical presentations of autoimmune encephalitis patients in imaging and cerebrospinal fluid diagnostics and also in prognostic markers, in the establishment of innovative immunotherapies, in the use of diagnostic pathways even before the results of the antibody tests are available and the understanding of the autoimmune etiology.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes do Sistema Nervoso
/
Encefalite
/
Doença de Hashimoto
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
De
Revista:
Nervenarzt
Ano de publicação:
2023
Tipo de documento:
Article