<i>Ziziphus abyssinica</i> root bark extract ameliorates paracetamol-induced liver toxicity in rats possibly via the attenuation of oxidative stress.

Henneh, Isaac Tabiri; Ahlidja, Wisdom; Alake, John; Kwabil, Augustine; Ahmed, Mustapha Abubakar; Kyei-Asante, Baffour; Adinortey, Michael Buenor; Ekor, Martins; Armah, Francis Ackah

Ziziphus abyssinica root bark extract ameliorates paracetamol-induced liver toxicity in rats possibly via the attenuation of oxidative stress.

Henneh, Isaac Tabiri; Ahlidja, Wisdom; Alake, John; Kwabil, Augustine; Ahmed, Mustapha Abubakar; Kyei-Asante, Baffour; Adinortey, Michael Buenor; Ekor, Martins; Armah, Francis Ackah.

Afiliação

Henneh IT; Department of Pharmacotherapeutics and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
Ahlidja W; Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Alake J; Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Kwabil A; Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Ahmed MA; Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Kyei-Asante B; Small Animal Teaching Hospital, School of Veterinary Medicine, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana.
Adinortey MB; Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
Ekor M; Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana.
Armah FA; Department of Pharmacology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.

Toxicol Rep ; 9: 1929-1937, 2022.

Article em En | MEDLINE | ID: mdl-36518453

Palavras-chave

AA, Ascorbic acid; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, Aspartate aminotransferase; Acetaminophen; Antioxidant; CA, Catechin; CAT, Catalase; DMSO, Dimethyl sulfoxide; DPPH, 1,1-diphenyl-2-picrylhydrazyl; DRSA, DPPH radical scavenging assay; DTNB, 5,5-dithiobis-(2-nitrobenzoic acid); EDTA, Ethylenediamine tetraacetic acid; GA, Gallic acid; GSH, Gluthathione; Hepatoprotection; Liver injury; NAC, N-acetylcysteine, PILT, Paracetamol-induced liver hepatotoxicity; NO, Nitric oxide; PCM, Paracetamol; Rhamnaceae; TCA, Trichloroacetic acid; ZAE, Ethanolic root bark extract of Ziziphus abyssinica; Ziziphus abyssinica

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Gana

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Toxicol Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Gana