Cardiomyocyte-specific Peli1 contributes to the pressure overload-induced cardiac fibrosis through miR-494-3p-dependent exosomal communication.

Tang, Chao; Hou, Yu-Xing; Shi, Peng-Xi; Zhu, Cheng-Hao; Lu, Xia; Wang, Xiao-Lu; Que, Lin-Li; Zhu, Guo-Qing; Liu, Li; Chen, Qi; Li, Chuan-Fu; Xu, Yong; Li, Jian-Tao; Li, Yue-Hua

Tang, Chao; Hou, Yu-Xing; Shi, Peng-Xi; Zhu, Cheng-Hao; Lu, Xia; Wang, Xiao-Lu; Que, Lin-Li; Zhu, Guo-Qing; Liu, Li; Chen, Qi; Li, Chuan-Fu; Xu, Yong; Li, Jian-Tao; Li, Yue-Hua.

Afiliação

Tang C; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Hou YX; Department of Pathology and Pathophysiology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Shi PX; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Zhu CH; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Lu X; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Wang XL; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Que LL; Shanghai JiaoTong University Affiliated Sixth People's Hospital, Shanghai, China.
Zhu GQ; Center of Clinical Research, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Liu L; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Chen Q; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Department of Physiology, Nanjing Medical University, Nanjing, China.
Li CF; Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xu Y; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
Li JT; Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA.
Li YH; Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.

FASEB J ; 37(1): e22699, 2023 01.

Article em En | MEDLINE | ID: mdl-36520055

Assuntos

Comunicação Celular; Exossomos; Insuficiência Cardíaca; Miócitos Cardíacos; Humanos; Exossomos/genética; Exossomos/metabolismo; Fibrose/etiologia; Fibrose/genética; Fibrose/metabolismo; Fibrose/patologia; Insuficiência Cardíaca/genética; Insuficiência Cardíaca/metabolismo; Insuficiência Cardíaca/patologia; MicroRNAs/genética; MicroRNAs/metabolismo; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; NF-kappa B/genética; NF-kappa B/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Fator de Transcrição AP-1/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Cardiopatias/etiologia; Cardiopatias/genética; Cardiopatias/metabolismo; Cardiopatias/patologia; Fibroblastos/metabolismo; Fibroblastos/patologia; Comunicação Celular/genética; Comunicação Celular/fisiologia

Palavras-chave

PTEN; Peli1; cardiac fibrosis; exosomes; miR-494-3p; paracrine signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comunicação Celular / Miócitos Cardíacos / Exossomos / Insuficiência Cardíaca Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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