Your browser doesn't support javascript.
loading
A practical approach for PD-L1 evaluation in gastroesophageal cancer.
Angerilli, Valentina; Fassan, Matteo; Parente, Paola; Gullo, Irene; Campora, Michela; Rossi, Chiara; Sacramento, Maria Luisa; Pennelli, Gianmaria; Vanoli, Alessandro; Grillo, Federica; Mastracci, Luca.
Afiliação
  • Angerilli V; Department of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua (PD), Italy.
  • Fassan M; Department of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua (PD), Italy.
  • Parente P; Veneto Institute of Oncology IOV - IRCCS, Padua (PD), Italy.
  • Gullo I; Unit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy.
  • Campora M; Department of Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal.
  • Rossi C; Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Portugal.
  • Sacramento ML; i3S - Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Portugal.
  • Pennelli G; Public Healthcare Trust of the Autonomous Province of Trento, Santa Chiara Hospital, Department of Laboratory Medicine, Pathology Unit, Trento, Italy.
  • Vanoli A; Anatomic Pathology Unit, Department of Molecular Medicine, University of Pavia, and IRCCS San Matteo Hospital, Pavia, Italy.
  • Grillo F; Department of Pathology, Centro Hospitalar Universitário de São João (CHUSJ), Porto, Portugal.
  • Mastracci L; Department of Medicine (DIMED), Surgical Pathology Unit, University Hospital of Padua, Padua (PD), Italy.
Pathologica ; 115(2): 57-70, 2023 Apr.
Article em En | MEDLINE | ID: mdl-36537078
ABSTRACT
PD-L1 is an established predictive immunohistochemical biomarker of response to immune checkpoint inhibitors. At present, PD-L1 is routinely assessed on biopsy samples of advanced gastroesophageal cancer patients before initiating first-line treatment. However, PD-L1 is still a suboptimal biomarker, due to changing cut-off values and scoring systems, interobserver and interlaboratory variability.This practical illustrated review discusses the range of staining patterns of PD-L1 and the potential pitfalls and challenges that can be encountered when evaluating PD-L1, focusing on gastric and gastroesophageal adenocarcinoma (G/GEA) and esophageal squamous cell carcinoma (ESCC).
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias Esofágicas / Adenocarcinoma / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Pathologica Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias Esofágicas / Adenocarcinoma / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Pathologica Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália