Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an &#945;5-GABAA receptor NAM.

Károlyi, Benedek Imre; Potor, Attila; Kapus, Gábor László; Fodor, László; Bobok, Amrita; Krámos, Balázs; Magdó, Ildikó; Bata, Imre; Szabó, György

Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM.

Károlyi, Benedek Imre; Potor, Attila; Kapus, Gábor László; Fodor, László; Bobok, Amrita; Krámos, Balázs; Magdó, Ildikó; Bata, Imre; Szabó, György.

Afiliação

Károlyi BI; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary. Electronic address: karolyibi@richter.hu.
Potor A; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Kapus GL; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Fodor L; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Bobok A; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Krámos B; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Magdó I; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Bata I; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Szabó G; Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.

Bioorg Med Chem Lett ; 80: 129107, 2023 01 15.

Article em En | MEDLINE | ID: mdl-36549396

Assuntos

Quinoxalinas; Receptores de GABA-A; Quinoxalinas/farmacologia

Palavras-chave

Displacement; Imidazo[1,5-a]quinoxaline; Modelling; Patch clamp; SAR; Selectivity; α5-GABA(A) modulator

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinoxalinas / Receptores de GABA-A Tipo de estudo: Diagnostic_studies Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2023 Tipo de documento: Article

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