[Coxsackievirus B infection and pathogenesis of type 1 diabetes]. / Infection à coxsackievirus B et pathogenèse du diabète de type 1.
Virologie (Montrouge)
; 26(6): 415-430, 2022.
Article
em Fr
| MEDLINE
| ID: mdl-36565260
ABSTRACT
Epidemiological and experimental studies suggest that enteroviruses (EV) and particularly coxsackieviruses B (CVB) are likely to trigger or accelerate the onset of islet autoimmunity and the development of type 1 diabetes (T1D) in genetically susceptible individuals. Several mutually non-exclusive mechanisms have been proposed to explain the involvement of CVB in the pathogenesis of T1D. CVB can infect and persist in the intestine, thymic cells, monocytes/macrophages, ductal cells and pancreatic ß-cells, which leads to structural or functional alterations of these cells. A chronic inflammatory response and disruption of tolerance towards ß-cells due to CVB infections are able to promote the recruitment and activation of pre-existing autoreactive T-cells and the destruction of ß-cells. Vaccine or therapeutic strategies to control EV infections have been developed and open perspectives for the prevention or treatment of T1D.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Enterovirus
/
Infecções por Coxsackievirus
/
Diabetes Mellitus Tipo 1
/
Infecções por Enterovirus
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
Fr
Revista:
Virologie (Montrouge)
Ano de publicação:
2022
Tipo de documento:
Article