Dual photo-controlled release system for fipronil and dinotefuran.

Development of controlled release system promises a huge impact on the pesticide delivery, which has raised attentions in improving efficacy of pesticides. Herein, the emerging photoremovable protecting group (PRPG), used in spatiotemporal delivery of drug by light, was introduced into agriculture. We obtained three TNB-insecticides and two of them exhibited excellent photophysicochemical properties. Our dual photo-controlled release system displayed more than sixfold insecticidal activity differences upon irradiation with UV light or sunlight. The dual release of DIN-TNB-DIN showed synergistic effect on mosquito larvae and armyworm larvae. Distribution of the fluorescence in body of dead/alive wigglers clearly illustrated the action mode, and visually demonstrated the precise and spatiotemporal delivery of insecticides in the living mosquito larvae. The new developed dual photo-controlled release system might widen the diversity in pesticide delivery, promoting the development in improving pesticide efficacy.