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Determination of possible contraceptive potential of methanolic leaf extract of Mentha longifolia L. in adult male rats: a biochemical and histological study.
David, Mehwish; Ain, Qurat Ul; Jahan, Sarwat; Ahmad, Mushtaq; Shah, Qasim; Afsar, Tayyaba; Shafique, Huma; Alanezi, Tariq Nahar; Almajwal, Ali; Ijaz, Umar; Razak, Suhail.
Afiliação
  • David M; Reproductive Physiology Laboratory, Department of Zoology, Quaid-i-AzamUniversity, Islamabad, 45320, Pakistan.
  • Ain QU; Department of Zoology, Government College Women University, 51310, Sialkot, Pakistan.
  • Jahan S; Reproductive Physiology Laboratory, Department of Zoology, Quaid-i-AzamUniversity, Islamabad, 45320, Pakistan.
  • Ahmad M; Plant Systematics and Biodiversity Laboratory, Department of Plant Sciences, Quaid-i-Azam University Islamabad, 45320, Pakistan.
  • Shah Q; Reproductive Physiology Laboratory, Department of Zoology, Quaid-i-AzamUniversity, Islamabad, 45320, Pakistan.
  • Afsar T; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11481, Saudia Arabia.
  • Shafique H; Institute of Cellular Medicine, Newcastle University Medical School, NE17RU, United Kingdom.
  • Alanezi TN; College of Medicine, King Saud University, Riyadh, 11481, Saudi Arabia.
  • Almajwal A; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11481, Saudia Arabia.
  • Ijaz U; Department of Zoology, Wildlife, and Fisheries, University of Agriculture, Faisalabad, 38040, Pakistan.
  • Razak S; Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11481, Saudia Arabia.
Toxicol Res (Camb) ; 11(6): 951-961, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36569485
Mentha longifolia L (ML) is locally used as an herbal contraceptive. We aim to assess the toxicity profile and validate the antifertility effects of its leaves in male rats. Adult male Sprague Dawley rats (n = 10 animals/group) were divided into four groups. The Control group received .9% saline, while groups II, III, and IV received 50, 75, and 100 mg/kg/day ML doses for 28 days. ML induced a dose-dependent decrease in percent fertility as well as the number of pups born in ML preexposed pairs, with maximum change observed in the ML3 group (60%, 3.75 ± 1.25) as compared to control (100%, 8.75 ± .48) group. A significant (P < .01) decrease in the rate of daily sperm production was observed in the ML3 group (.86 ± .16) in contrast to the control (2.93 ± .05). The levels of catalase and superoxide dismutase declined significantly in treatment groups (ML1-P < .001, ML2-P < .05, and ML3-P < .01). A significant increase in the production of reactive oxygen species (P < .001) was found in all treatment groups. The concentrations of LH (P < .001), FSH (P < .001), and testosterone (P < .001) were significantly reduced in a dose-dependent manner among ML-treated groups. Decreases in spermatogonial populations, mature spermatids, seminiferous tubule diameter, lumen diameter, and epithelial height were noticed at higher doses. The reversibility study depicted a reduction in both pregnancy outcomes and litter size. Besides contraceptive effects, M. longifolia L usage is associated with oxidative stress; therefore, it is important to consume this herb appropriately and its excessive usage should be prohibited.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Toxicol Res (Camb) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão