The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.

Proença, Susana; van Sabben, Nick; Legler, Juliette; Kamstra, Jorke H; Kramer, Nynke I

Proença, Susana; van Sabben, Nick; Legler, Juliette; Kamstra, Jorke H; Kramer, Nynke I.

Afiliação

Proença S; Department of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Toxicology Division, Wageningen University, Wageningen, the Netherlands. Electronic address: susana.proenca@wur.nl.
van Sabben N; Department of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Legler J; Department of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Kamstra JH; Department of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands.
Kramer NI; Department of Toxicology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands; Toxicology Division, Wageningen University, Wageningen, the Netherlands.

Toxicology ; 485: 153411, 2023 02.

Article em En | MEDLINE | ID: mdl-36572169

Assuntos

Fígado; Transcriptoma; Humanos; Hepatócitos; Receptores Citoplasmáticos e Nucleares/genética; Receptores Citoplasmáticos e Nucleares/metabolismo; Hormônios Tireóideos/metabolismo

Palavras-chave

HBCD; HepaRG; PXR; Sandwich; Spheroids; Thyroid hormones

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transcriptoma / Fígado Limite: Humans Idioma: En Revista: Toxicology Ano de publicação: 2023 Tipo de documento: Article

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