Effects of peristaltic amplitude and frequency on gastric emptying and mixing: a simulation study.
J R Soc Interface
; 20(198): 20220780, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36596453
ABSTRACT
The amplitude and frequency of peristaltic contractions are two major parameters for assessing gastric motility. However, it is not fully understood how these parameters affect the important functions of the stomach, such as gastric mixing and emptying. This study aimed to quantify the effects of peristaltic amplitude and frequency on gastric mixing and emptying using computational fluid dynamics simulation of gastric flow with an anatomically realistic model of the stomach. Our results suggest that both the increase and decrease in peristaltic amplitude have a significant impact on mixing strength and emptying rate. For example, when the peristaltic amplitude was 1.2 times higher than normal, the emptying rate was 2.7 times faster, whereas when the amplitude was half, the emptying rate was 4.2 times slower. Moreover, the emptying rate increased more than proportionally with the peristaltic frequency. The nearest contraction wave to the pylorus and the subsequent waves promoted gastric emptying. These results suggest the importance of maintaining parameters within normal ranges to achieve healthy gastric function.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estômago
/
Esvaziamento Gástrico
Idioma:
En
Revista:
J R Soc Interface
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Japão