Hallmarks of aging: An expanding universe.
Cell
; 186(2): 243-278, 2023 01 19.
Article
em En
| MEDLINE
| ID: mdl-36599349
ABSTRACT
Aging is driven by hallmarks fulfilling the following three premises (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. We propose the following twelve hallmarks of aging genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress.
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1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
Idioma:
En
Revista:
Cell
Ano de publicação:
2023
Tipo de documento:
Article