Role of the caspase-8/RIPK3 axis in Alzheimer's disease pathogenesis and Aß-induced NLRP3 inflammasome activation.

Kumar, Sushanth; Budhathoki, Sakar; Oliveira, Christopher B; Kahle, August D; Calhan, O Yipkin; Lukens, John R; Deppmann, Christopher D

Kumar, Sushanth; Budhathoki, Sakar; Oliveira, Christopher B; Kahle, August D; Calhan, O Yipkin; Lukens, John R; Deppmann, Christopher D.

Afiliação

Kumar S; Department of Biology and.
Budhathoki S; Neuroscience Graduate Program, School of Medicine, and.
Oliveira CB; Department of Biology and.
Kahle AD; Department of Biology and.
Calhan OY; Department of Biology and.
Lukens JR; Department of Biology and.
Deppmann CD; Neuroscience Graduate Program, School of Medicine, and.

JCI Insight ; 8(3)2023 02 08.

Article em En | MEDLINE | ID: mdl-36602874

Assuntos

Doença de Alzheimer; Amiloidose; Animais; Humanos; Camundongos; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/metabolismo; Caspase 8/metabolismo; Modelos Animais de Doenças; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteína Serina-Treonina Quinases de Interação com Receptores/metabolismo

Palavras-chave

Alzheimer disease; Apoptosis pathways; Inflammation; Innate immunity; Neuroscience

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Amiloidose Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: JCI Insight Ano de publicação: 2023 Tipo de documento: Article

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