Evading the Toll booth: How "silent" flagellins may bind yet fail to activate TLR5.

Baer, Hannah M; Sandilya, Shruti; Steiner, Theodore S

Baer, Hannah M; Sandilya, Shruti; Steiner, Theodore S.

Afiliação

Baer HM; BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Sandilya S; Institute of Infection, Inflammation & Immunity, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Steiner TS; BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Sci Immunol ; 8(79): eadf0244, 2023 01 06.

Article em En | MEDLINE | ID: mdl-36608148

ABSTRACT

ABSTRACT

The nature of flagellin-Toll-like receptor 5 (TLR5) interactions, depending on binding to and activation of TLR5, may hold a key to the distinct differences in gut microbiome and intestinal immune function in different populations around the world (see related Research Article by Clasen et al.).

Assuntos

Flagelina; Receptor 5 Toll-Like; Flagelina/metabolismo; Intestinos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 5 Toll-Like / Flagelina Idioma: En Revista: Sci Immunol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

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