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Transcriptomic response and immunological responses to chimpanzee adenovirus- and MVA viral-vectored vaccines for RSV in healthy adults.
Green, C; McGinley, J; Sande, C; Capone, S; Makvandi-Nejad, S; Vitelli, A; Silva-Reyes, L; Bibi, S; Otasowie, C; Sheerin, D; Thompson, A; Dold, C; Klenerman, P; Barnes, E; Dorrell, L; Rollier, C; Pollard, A; O'Connor, D.
Afiliação
  • Green C; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • McGinley J; Institute of Microbiology & Infection, University of Birmingham, Birmingham, UK.
  • Sande C; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Capone S; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Makvandi-Nejad S; Experimental Vaccinology Department, ReiThera Srl, Roma, Italy.
  • Vitelli A; Nuffield Department of Medicine, University of Oxford NDM Research Building, Oxford, UK.
  • Silva-Reyes L; Experimental Vaccinology Department, ReiThera Srl, Roma, Italy.
  • Bibi S; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Otasowie C; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Sheerin D; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Thompson A; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Dold C; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Klenerman P; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • Barnes E; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Dorrell L; Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Rollier C; Nuffield Department of Medicine, University of Oxford NDM Research Building, Oxford, UK.
  • Pollard A; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
  • O'Connor D; Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.
Clin Exp Immunol ; 211(3): 269-279, 2023 03 24.
Article em En | MEDLINE | ID: mdl-36622786
Cohorts of healthy younger adults (18-50yrs) and healthy older adults (60-75yrs) were immunized intramuscularly or intranasally with an adenovirus-vectored RSV vaccine (PanAd3-RSV) as a prime dose and boosted with PanAd3-RSV or a poxvirus-vectored vaccine (MVA-RSV) encoding the same insert. Whole blood gene expression was measured at baseline, 3- and 7-days post vaccination. Intramuscular prime vaccination with PanAd3-RSV induced differential expression of 643 genes (DEGs, FDR < 0.05). Intranasal prime vaccination with PanAd3-RSV did not induce any differentially expressed genes (DEGs) in blood samples at 3 days post vaccination. Intranasally primed participants showed greater numbers of DEGS on boosting than intramuscularly primed participants. The most highly enriched biological processes related to DEGs after both prime and boost vaccination were type-1 interferon related pathways, lymphocytic and humoral immune responses.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pan troglodytes / Transcriptoma Limite: Aged / Animals / Humans Idioma: En Revista: Clin Exp Immunol Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pan troglodytes / Transcriptoma Limite: Aged / Animals / Humans Idioma: En Revista: Clin Exp Immunol Ano de publicação: 2023 Tipo de documento: Article