Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor &#945; Axis.

Zhou, QiQi; Yang, Liuqing; Verne, Meghan L; Zhang, Benjamin B; Fields, Jeremy; Verne, George Nicholas

Catechol-O-Methyltransferase Loss Drives Cell-Specific Nociceptive Signaling via the Enteric Catechol-O-Methyltransferase/microRNA-155/Tumor Necrosis Factor α Axis.

Zhou, QiQi; Yang, Liuqing; Verne, Meghan L; Zhang, Benjamin B; Fields, Jeremy; Verne, George Nicholas.

Afiliação

Zhou Q; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Memphis Veterans Affairs Medical Center, Research Service, Memphis, Tennessee.
Yang L; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Verne ML; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Zhang BB; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Fields J; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Verne GN; Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Memphis Veterans Affairs Medical Center, Research Service, Memphis, Tennessee. Electronic address: gverne@tennessee.edu.

Gastroenterology ; 164(4): 630-641.e34, 2023 04.

Article em En | MEDLINE | ID: mdl-36623778

Assuntos

Síndrome do Intestino Irritável; MicroRNAs; Humanos; Camundongos; Animais; Síndrome do Intestino Irritável/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Catecol O-Metiltransferase/genética; Catecol O-Metiltransferase/metabolismo; Nociceptividade; Inibidores do Fator de Necrose Tumoral; Colo/metabolismo; Dor Abdominal/genética; Dor Abdominal/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Trinitrobenzenos/metabolismo; Ácidos Sulfônicos/metabolismo

Palavras-chave

Abdominal Pain; Catechol-O-Methyltransferase; Irritable Bowel Syndrome; Visceral Hypersensitivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Síndrome do Intestino Irritável Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2023 Tipo de documento: Article

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