Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase.

Bearne, Stephen L

Bearne, Stephen L.

Afiliação

Bearne SL; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2.

Philos Trans R Soc Lond B Biol Sci ; 378(1871): 20220041, 2023 02 27.

Article em En | MEDLINE | ID: mdl-36633273

Assuntos

Racemases e Epimerases; Entropia; Catálise; Cinética

Palavras-chave

binding free energy; enzyme inhibition; inhibitor design; mandelate racemase; transition state analogue inhibitors; transition state stabilization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Racemases e Epimerases Idioma: En Revista: Philos Trans R Soc Lond B Biol Sci Ano de publicação: 2023 Tipo de documento: Article

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