Study of Adherence to Medication in Pediatric Liver Diseases ("SAMPLD" Study) in Indian Children.
J Clin Exp Hepatol
; 13(1): 22-30, 2023.
Article
em En
| MEDLINE
| ID: mdl-36647409
ABSTRACT
Background/objectives:
Adherence to medication(s) is an essential component of holistic management in any chronic disease including in post liver transplant (LT) patients. Thus, this study aimed to assess adherence to medications in Indian pediatric liver disease patients (including post LT recipients) and to identify variables affecting its occurrence.Methods:
A cross-sectional study was conducted among pediatric (<18 years of age) subjects with Wilson disease (WD) and autoimmune liver disease (AILD) along with post LT recipients from May 2021 to October 2021. Structured tools using prevalidated questionnaires (Medication adherence measure and the Child & Adolescent Adherence to Medication Questionnaire) were used to collect data related to nonadherence prevalence (based on missed and late doses) and factors influencing the adherence.Results:
A total of 152 children were included in the study (WD 39.5%, AILD 32.9%, and post LT 27.6%). Prevalence of missed and late dose nonadherence (at a cut-off of ≥20%) was 12.5% and 16.4%, respectively. Older age (odd's ratio/O.R 1.185), stay in a rural area (O.R 5.08), and barriers like bad taste of medication (O.R 4.728) and hard to remember the medication (O.R 7.180) were independently associated with nonadherence (P < 0.05).Conclusions:
Overall, nonadherence was seen in 12-16%, i.e., around one-sixth of the patients, with least nonadherence seen in post LT recipients (0-2.4%). Older age of the patient, rural place of stay and personal barriers like hard to remember/forgetfulness and bad medication taste were identified as factors independently leading to nonadherence.
AILD, Autoimmune liver disease; CAAMQ, The Child & Adolescent Adherence to Medication Questionnaire; LT, liver transplant; WD, Wilson disease; child & adolescent adherence to medication questionnaire; medication adherence measure; non adherence to medications; pediatric liver diseases; post liver transplant recipients
Texto completo:
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Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Idioma:
En
Revista:
J Clin Exp Hepatol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Índia