The use of occlusive dressings: influence on excisional wound healing in animal model.
Acta Cir Bras
; 37(12): e371206, 2023.
Article
em En
| MEDLINE
| ID: mdl-36651431
ABSTRACT
PURPOSE:
To analyze the influence of occlusive dressing on the healing of excisional skin wounds in mice.METHODS:
Pre-clinical, comparative, and translational study. Mice were divided into three experimental groups wounds occluded with hydrocolloid (HD) dressings, transparent polyurethane film (TF) dressings, and without occlusion (WO), monitored at three, six and 14 days, with eight animals each. Closure rate, infiltration of neutrophils and macrophages, measurement of tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) and, histologically, angiogenesis were evaluated.RESULTS:
Wound closure was accelerated in the occlusive groups. There was a decrease in TNF-α levels in the HD group when compared to the WO and TF groups. Neutrophils accumulation decreased in the HD group. Increased dosages of macrophages were evidenced in the HD group, compared to the WO and TF groups. Levels of VEGF were increased in the TF and HD groups.CONCLUSIONS:
It is suggested that the occlusion of wounds modulates the inflammatory response.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Curativos Oclusivos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Brasil