Anti-inflammatory activity of fluorine-substituted benzo[h]quinazoline-2-amine derivatives as NF-&#954;B inhibitors.

Luan, Ming-Zhu; Zhang, Xiao-Fan; Yang, Yang; Meng, Qing-Guo; Hou, Gui-Ge

Anti-inflammatory activity of fluorine-substituted benzo[h]quinazoline-2-amine derivatives as NF-κB inhibitors.

Luan, Ming-Zhu; Zhang, Xiao-Fan; Yang, Yang; Meng, Qing-Guo; Hou, Gui-Ge.

Afiliação

Luan MZ; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, PR China; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai Univer
Zhang XF; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China.
Yang Y; School of Basic Medical Sciences, Binzhou Medical University, Yantai 264003, PR China.
Meng QG; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China. Electronic address:
Hou GG; School of Pharmacy, the Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai 264003, PR China. Electronic address: guigehou@163.com.

Bioorg Chem ; 132: 106360, 2023 03.

Article em En | MEDLINE | ID: mdl-36652807

Assuntos

Inflamassomos; NF-kappa B; Humanos; NF-kappa B/metabolismo; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Flúor; Anti-Inflamatórios/farmacologia; Inflamação/tratamento farmacológico; Inflamação/metabolismo

Palavras-chave

3,4-dihydronaphthalen-1(2H)-one; Anti-inflammatory activity; Benzo[h]quinazoline-2-amine; NF-κB inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Inflamassomos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2023 Tipo de documento: Article

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