Reversible switching between two common protein folds in a designed system using only temperature.

Solomon, Tsega L; He, Yanan; Sari, Nese; Chen, Yihong; Gallagher, D Travis; Bryan, Philip N; Orban, John

Reversible switching between two common protein folds in a designed system using only temperature.

Solomon, Tsega L; He, Yanan; Sari, Nese; Chen, Yihong; Gallagher, D Travis; Bryan, Philip N; Orban, John.

Afiliação

Solomon TL; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850.
He Y; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Sari N; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850.
Chen Y; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850.
Gallagher DT; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850.
Bryan PN; W. M. Keck Laboratory for Structural Biology, University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850.
Orban J; National Institute of Standards and Technology, Rockville, MD 20850.

Proc Natl Acad Sci U S A ; 120(4): e2215418120, 2023 Jan 24.

Article em En | MEDLINE | ID: mdl-36669114

Assuntos

Dobramento de Proteína; Proteínas; Temperatura; Proteínas/química; Mutação; Substituição de Aminoácidos

Palavras-chave

NMR; metamorphic proteins; protein design; protein fold switching; protein structure and dynamics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Dobramento de Proteína Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2023 Tipo de documento: Article

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