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On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153.
Moskaliuk, Vitalii S; Kozhemyakina, Rimma V; Khomenko, Tatyana M; Volcho, Konstantin P; Salakhutdinov, Nariman F; Kulikov, Alexander V; Naumenko, Vladimir S; Kulikova, Elizabeth A.
Afiliação
  • Moskaliuk VS; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentyeva Ave., 630090 Novosibirsk, Russia.
  • Kozhemyakina RV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentyeva Ave., 630090 Novosibirsk, Russia.
  • Khomenko TM; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9 Akad. Lavrentieva Ave., 630090 Novosibirsk, Russia.
  • Volcho KP; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9 Akad. Lavrentieva Ave., 630090 Novosibirsk, Russia.
  • Salakhutdinov NF; N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, SB RAS, 9 Akad. Lavrentieva Ave., 630090 Novosibirsk, Russia.
  • Kulikov AV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentyeva Ave., 630090 Novosibirsk, Russia.
  • Naumenko VS; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentyeva Ave., 630090 Novosibirsk, Russia.
  • Kulikova EA; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 10 Akad. Lavrentyeva Ave., 630090 Novosibirsk, Russia.
Int J Mol Sci ; 24(2)2023 Jan 04.
Article em En | MEDLINE | ID: mdl-36674499
ABSTRACT
The Bdnf (brain-derived neurotrophic factor) gene contains eight regulatory exons (I-VIII) alternatively spliced to the protein-coding exon IX. Only exons I, II, IV, and VI are relatively well studied. The BDNF system and brain serotonergic system are tightly interconnected and associated with aggression. The benzopentathiepine TC-2153 affects both systems and exerts antiaggressive action. Our aim was to evaluate the effects of TC-2153 on the Bdnf exons I-IX's expressions and serotonin receptors' mRNA levels in the brain of rats featuring high aggression toward humans (aggressive) or its absence (tame). Aggressive and tame adult male rats were treated once with vehicle or 10 or 20 mg/kg of TC-2153. mRNA was quantified in the cortex, hippocampus, hypothalamus, and midbrain with real-time PCR. Selective breeding for high aggression or its absence affected the serotonin receptors' and Bdnf exons' transcripts differentially, depending on the genotype (strain) and brain region. TC-2153 had comprehensive effects on the Bdnf exons' expressions. The main trend was downregulation in the hypothalamus and midbrain. TC-2153 increased 5-HT1B receptor hypothalamusc mRNA expression. For the first time, an influence of TC-2153 on the expressions of Bdnf regulatory exons and the 5-HT1B receptor was shown, as was an association between Bdnf regulatory exons and fear-induced aggression involving genetic predisposition.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Receptor 5-HT1B de Serotonina Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Federação Russa

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Receptor 5-HT1B de Serotonina Tipo de estudo: Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Federação Russa