Detection of ß-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer's disease patients using UHPLC-MS/MS: An autopsy case-series study.

Garamszegi, Susanna P; Banack, Sandra Anne; Duque, Linda L; Metcalf, James S; Stommel, Elijah W; Cox, Paul Alan; Davis, David A

Garamszegi, Susanna P; Banack, Sandra Anne; Duque, Linda L; Metcalf, James S; Stommel, Elijah W; Cox, Paul Alan; Davis, David A.

Afiliação

Garamszegi SP; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Banack SA; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson, WY 83001, USA.
Duque LL; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Metcalf JS; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson, WY 83001, USA.
Stommel EW; Department of Neurology, Dartmouth-Hitchcock Medical Center Department of Neurology, One Medical Center Dr., Lebanon, NH 03756, USA.
Cox PA; Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Davis DA; Brain Chemistry Labs, Institute for Ethnomedicine, Jackson, WY 83001, USA.

Toxicol Rep ; 10: 87-96, 2023.

Article em En | MEDLINE | ID: mdl-36691605

Palavras-chave

2,4-DAB, 2,4-diaminobutyric acid; AD, Alzheimer's disease; AEG, N-(2-aminoethyl)glycine; ALS/PDC, Amyotrophic lateral sclerosis/ parkinsonism dementia complex; BMAA, ß-N-methylamino-l-alanine; CBs, Cyanobacterial blooms; Cyanobacteria; Cyanotoxin; IL-6; Inflammation; OD, Olfactory dysfunction; Ob, Olfactory bulb; Olfactory dysfunction; Ot, Olfactory tract; UHPLC-MS/MS, Ultra-performance liquid chromatography and tandem mass spectrometry

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Toxicol Rep Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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