Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models.
J Toxicol Environ Health B Crit Rev
; 26(2): 67-96, 2023 02 17.
Article
em En
| MEDLINE
| ID: mdl-36692141
ABSTRACT
Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relationship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an overview of the available human respiratory models and exposure systems for in vitro testing, advantages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Nanopartículas
Limite:
Humans
Idioma:
En
Revista:
J Toxicol Environ Health B Crit Rev
Assunto da revista:
SAUDE AMBIENTAL
/
TOXICOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Portugal