Perampanel: Medical Alternative for Essential Tremor?
Clin Neuropharmacol
; 46(2): 51-54, 2023.
Article
em En
| MEDLINE
| ID: mdl-36695601
ABSTRACT
OBJECTIVES:
The aim of this study was to assess the safety and efficacy of perampanel in patients with refractory essential tremor (ET).METHODS:
We recruited patients from our movement disorders clinic with the diagnosis of severe refractory ET, and perampanel 4 mg at night was initiated.Assessments were conducted at baseline and after 1 month of treatment with perampanel 4 mg/d. Details about tolerance and effectiveness were collected. Clinical evaluation was conducted with the Fahn-Tolosa-Marín scale, and statistical analysis was carried out with Wilcoxon matched pairs signed rank test.RESULTS:
This study included 18 patients with severe ET (11 females, 7 males; mean age 75.1 ± 12.03 years; mean duration of ET 17.4 ± 17.03 years). Perampanel significantly improved patients' average score with refractory ET ( P ≤ 0.0001). This improvement has been occasionally quite relevant. However, a proportion of patients did not tolerate perampanel because of several adverse effects including dizziness, ataxia, irritability, and instability.CONCLUSIONS:
Perampanel had a markedly positive antitremor effect in patients with ET and could be an alternative treatment. However, this drug is not devoid of adverse effects.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tremor Essencial
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Neuropharmacol
Ano de publicação:
2023
Tipo de documento:
Article