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Processing of social and monetary rewards in autism spectrum disorders.
Baumeister, Sarah; Moessnang, Carolin; Bast, Nico; Hohmann, Sarah; Aggensteiner, Pascal; Kaiser, Anna; Tillmann, Julian; Goyard, David; Charman, Tony; Ambrosino, Sara; Baron-Cohen, Simon; Beckmann, Christian; Bölte, Sven; Bourgeron, Thomas; Rausch, Annika; Crawley, Daisy; Dell'Acqua, Flavio; Dumas, Guillaume; Durston, Sarah; Ecker, Christine; Floris, Dorothea L; Frouin, Vincent; Hayward, Hannah; Holt, Rosemary; Johnson, Mark H; Jones, Emily J H; Lai, Meng-Chuan; Lombardo, Michael V; Mason, Luke; Oakley, Bethany; Oldehinkel, Marianne; Persico, Antonio M; San José Cáceres, Antonia; Wolfers, Thomas; Loth, Eva; Murphy, Declan G M; Buitelaar, Jan K; Tost, Heike; Meyer-Lindenberg, Andreas; Banaschewski, Tobias; Brandeis, Daniel.
Afiliação
  • Baumeister S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Moessnang C; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Bast N; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany and Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goeth
  • Hohmann S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Aggensteiner P; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Kaiser A; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Tillmann J; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom and Department of Applied Psychology: Health, Development, Enhancement, and Intervention, University of Vienna, Vienna, Austria.
  • Goyard D; Neurospin Centre CEA, Saclay, Gif sur Yvette, France.
  • Charman T; Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Ambrosino S; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
  • Baron-Cohen S; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK.
  • Beckmann C; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Bölte S; Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet and Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden and School of Allied Health, University of Wester
  • Bourgeron T; Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.
  • Rausch A; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Crawley D; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Dell'Acqua F; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Dumas G; Institut Pasteur, Human Genetics and Cognitive Functions Unit, Paris, France.
  • Durston S; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, the Netherlands.
  • Ecker C; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goethe University, Frankfurt, Germany.
  • Floris DL; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands and Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerl
  • Frouin V; Neurospin Centre CEA, Saclay, Gif sur Yvette, France.
  • Hayward H; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
  • Holt R; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK.
  • Johnson MH; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK and Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.
  • Jones EJH; Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
  • Lai MC; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK; Centre for Addiction and Mental Health and The Hospital for Sick Children, Department of Psychiatry, University of Toronto, Canada and Department of Psychiatry, National Taiwan University Hospital and College of Medicine,
  • Lombardo MV; Autism Research Centre, Department of Psychiatry, University of Cambridge, UK and Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Italy.
  • Mason L; Centre for Brain and Cognitive Development, Birkbeck, University of London, UK.
  • Oakley B; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK.
  • Oldehinkel M; Donders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, the Netherlands.
  • Persico AM; Child and Adolescent Neuropsychiatry Program at Modena University Hospital, & Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy.
  • San José Cáceres A; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK and Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón and CIBERSAM, Spain.
  • Wolfers T; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands and Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands.
  • Loth E; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Murphy DGM; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK and Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Buitelaar JK; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, the Netherlands and Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, the Netherlands.
  • Tost H; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Meyer-Lindenberg A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Brandeis D; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital, University of Zurich, Zurich,
Br J Psychiatry ; 222(3): 100-111, 2023 03.
Article em En | MEDLINE | ID: mdl-36700346
ABSTRACT

BACKGROUND:

Reward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD.

AIMS:

Utilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD.

METHOD:

Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.6 years of age) and 181 typically developing participants (7.6-30.8 years of age).

RESULTS:

Across social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses, post hoc comparisons showed that ASD effects were most pronounced in participants with ASD without co-occurring ADHD.

CONCLUSIONS:

Our results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtorno Autístico / Transtorno do Espectro Autista Limite: Humans Idioma: En Revista: Br J Psychiatry Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno do Deficit de Atenção com Hiperatividade / Transtorno Autístico / Transtorno do Espectro Autista Limite: Humans Idioma: En Revista: Br J Psychiatry Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha