Enantiomeric pairs of macrocyclic acylphloroglucinols from Syzygium szemaoense.
Bioorg Chem
; 132: 106381, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36706532
ABSTRACT
Two enantiomeric pairs of macrocyclic acylphloroglucinols (1a/1b and 2a/2b) with an unprecedented carbon skeleton featuring a bicyclo[12.3.1]octadecane core, together with an undescribed biogenetically related long-chain acylphloroglucinol (3), were isolated from Syzygium szemaoense. Their structures were fully established by spectroscopic method, X-ray crystallographic analysis, and ECD calculation. Compounds 1b and 2a/2b exhibited inhibition against death-associated protein kinase-related apoptosis inducing protein kinase 2 (DRAK2) and ATP citrate lyase (ACLY), respectively.
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Base de dados:
MEDLINE
Assunto principal:
Syzygium
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2023
Tipo de documento:
Article