The sweet and sour sides of trypanosome social motility.
Trends Parasitol
; 39(4): 242-250, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36732111
ABSTRACT
Recent studies showed that the formation of elegant geometric patterns by communities of Trypanosoma brucei on semi-solid surfaces, dubbed social motility (SoMo) by its discoverers, is a manifestation of pH taxis. This is caused by procyclic forms generating and responding to pH gradients through glucose metabolism and cAMP signalling. These findings established that trypanosomes can sense and manipulate gradients, potentially helping them to navigate through host tissues. At the same time, the host itself and bystanders such as endosymbionts have the potential to shape the environment and influence the chances of successful transmission. We postulate that the ability to sense and contribute to the gradient landscape may also underlie the tissue tropism and migration of other parasites in their hosts.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma
/
Trypanosoma brucei brucei
/
Moscas Tsé-Tsé
Limite:
Animals
Idioma:
En
Revista:
Trends Parasitol
Assunto da revista:
PARASITOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos