Mobility mediates maturation: Synthetic substrates to enhance neural differentiation.

Roth, Julien G; Huang, Michelle S; Heilshorn, Sarah C

Roth, Julien G; Huang, Michelle S; Heilshorn, Sarah C.

Afiliação

Roth JG; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute & Bio-X, Stanford University, Stanford, CA, USA.
Huang MS; Department of Chemical Engineering, Stanford University, Stanford, CA, USA.
Heilshorn SC; Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute & Bio-X, Stanford University, Stanford, CA, USA; Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA. Electronic address: heilshorn@stanford.edu.

Cell Stem Cell ; 30(2): 115-117, 2023 02 02.

Article em En | MEDLINE | ID: mdl-36736286

RESUMO

The maturation of human induced pluripotent stem cell (hiPSC)-derived neurons in 2D is dependent upon cell attachment, spreading, and pathfinding across a biomaterial substrate. In this issue of Cell Stem Cell, Álvarez et al.1 demonstrate that highly mobile supramolecular scaffolds facilitate long-term hiPSC-derived motor neuron culture, increase maturation-related phenotypes, and recapitulate disease-relevant pathologies.

Assuntos

Células-Tronco Pluripotentes Induzidas; Humanos; Células Cultivadas; Diferenciação Celular/genética; Neurônios Motores

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes Induzidas Limite: Humans Idioma: En Revista: Cell Stem Cell Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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