Extending genetic risk for Alzheimer's disease from host to holobiont.

Kazmi, Sabeen A; Hsiao, Elaine Y

Kazmi, Sabeen A; Hsiao, Elaine Y.

Afiliação

Kazmi SA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sak14@g.ucla.edu.
Hsiao EY; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell ; 186(4): 690-692, 2023 02 16.

Article em En | MEDLINE | ID: mdl-36750093

ABSTRACT

ABSTRACT

The gut microbiota is implicated in risk for Alzheimer's disease (AD). A study in Science reports that depleting gut bacteria in mice with genetic risk for AD reduces neuropathology in a sex-dependent manner. This is reversed by administering short-chain fatty acids, suggesting that specific bacterial metabolites increase susceptibility to AD.

Assuntos

Doença de Alzheimer; Microbioma Gastrointestinal; Camundongos; Animais; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Microbioma Gastrointestinal/genética; Bactérias/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Microbioma Gastrointestinal Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google