The prevalence and predictors of herb-drug interactions among Iranian cancer patients during chemotherapy courses.
BMC Complement Med Ther
; 23(1): 41, 2023 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-36750849
ABSTRACT
BACKGROUND:
The concurrent usage of herbal medicines with conventional therapies is an important concern in cancer treatment which can lead to unexpected consequences like herb-drug interactions. This study aimed to determine the prevalence of potential herb-drug interactions and to predict factors associated with herb-drug interactions for cancer patients.METHODS:
This cross-sectional study was conducted among a convenience sample of 315 cancer patients referring to the oncology clinics of Kerman city in 2018. Data were collected via comprehensive face-to-face interviews and medical chart reviews. A drug interaction checker was used to determine herb-drug interactions. The information of patients was compared based on herb-drug interactions using bivariable logistic regression models, and predictors were determined by the multivariable logistic regression model. All analyses were performed by Stata software version 16.RESULTS:
Of 262 patients (83.2% of the patients) who used herbal medicines, 209 patients [79.8% (95% Confidence Intervals (CI) 75.2 - 85.1)] had potential herb-drug interactions. Chamomile was the most popular herbal medicine (n = 163, 78.0%), and minor and moderate herb-drug interactions were caused by green tea (n = 34, 16.3%) and peppermint (n = 78, 37.5%). The number of chemotherapeutic agents (OR 1.92, 95% CI 1.43-2.58; P-value < 0.0001) and the experienced of pain during chemotherapy courses (OR = 2.22, 95%CI1.00-4.94; P-value = 0.04) were some of the predictors of herb-drug interactions among cancer patients.CONCLUSION:
Herbal medicine use during chemotherapy was found prevalent among cancer patients; of them, the experience of potential herb-drug interactions was highly frequent. Oncologists and clinical pharmacologists are recommended to take into account challenges associated with herb-drug interactions in their routine practices, particularly during chemotherapy among these patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Neoplasias
Tipo de estudo:
Observational_studies
/
Prevalence_studies
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Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
BMC Complement Med Ther
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Irã