Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies.

Jung, Cha-Gyun; Yamashita, Hitoshi; Kato, Reiko; Zhou, Chunyu; Matsushita, Hiroaki; Takeuchi, Tamaki; Abdelhamid, Mona; Chen, Yuxin; Michikawa, Makoto

Jung, Cha-Gyun; Yamashita, Hitoshi; Kato, Reiko; Zhou, Chunyu; Matsushita, Hiroaki; Takeuchi, Tamaki; Abdelhamid, Mona; Chen, Yuxin; Michikawa, Makoto.

Afiliação

Jung CG; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Yamashita H; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan.
Kato R; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Zhou C; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan.
Matsushita H; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Takeuchi T; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan.
Abdelhamid M; Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501, Japan.
Chen Y; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
Michikawa M; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.

Int J Mol Sci ; 24(3)2023 Feb 01.

Article em En | MEDLINE | ID: mdl-36769062

Assuntos

Doença de Alzheimer; Camundongos; Animais; Doença de Alzheimer/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Temperatura Corporal; Proteína Desacopladora 1/metabolismo; Camundongos Transgênicos; Ácido Aspártico Endopeptidases/metabolismo; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/metabolismo; Encéfalo/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Modelos Animais de Doenças

Palavras-chave

Alzheimer's disease; Aß generation; BACE1; NEP; glial activation; heat shock proteins; high body temperature; synaptic proteins; tau; uncoupling protein 1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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