Vanoxerine kills mycobacteria through membrane depolarization and efflux inhibition.

Kingdon, Alexander D H; Meosa-John, Asti-Rochelle; Batt, Sarah M; Besra, Gurdyal S

Kingdon, Alexander D H; Meosa-John, Asti-Rochelle; Batt, Sarah M; Besra, Gurdyal S.

Afiliação

Kingdon ADH; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.
Meosa-John AR; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.
Batt SM; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.
Besra GS; School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.

Front Microbiol ; 14: 1112491, 2023.

Article em En | MEDLINE | ID: mdl-36778873

Palavras-chave

Mycobacterium tuberculosis; RNA sequencing; antibiotic; drug repurposing; efflux; mycobacteria; vanoxerine

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido