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A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.
Ong, Han Wee; Liang, Yi; Richardson, William; Lowry, Emily R; Wells, Carrow I; Chen, Xiangrong; Silvestre, Margaux; Dempster, Kelvin; Silvaroli, Josie A; Smith, Jeffery L; Wichterle, Hynek; Pabla, Navjot S; Ultanir, Sila K; Bullock, Alex N; Drewry, David H; Axtman, Alison D.
Afiliação
  • Ong HW; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America.
  • Liang Y; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America.
  • Richardson W; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
  • Lowry ER; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, 10032, United States of America; The Project ALS Therapeutics Core, Columbia University Irving Medical Center, New York, New York, 10032, United States of America.
  • Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America.
  • Chen X; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
  • Silvestre M; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Dempster K; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Silvaroli JA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, United States of America.
  • Smith JL; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America.
  • Wichterle H; Departments of Pathology and Cell Biology, Neurology, Neuroscience, Rehabilitation and Regenerative Medicine, Columbia University Irving Medical Center, New York, New York, 10032, United States of America; Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, New Yo
  • Pabla NS; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, 43210, United States of America.
  • Ultanir SK; Kinases and Brain Development Laboratory, The Francis Crick Institute, London, NW1 1AT, United Kingdom.
  • Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
  • Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America; UNC Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North
  • Axtman AD; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, United States of America.
bioRxiv ; 2023 Feb 10.
Article em En | MEDLINE | ID: mdl-36798313
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: BioRxiv Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos