Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrial­dependent apoptotic pathway and reducing &#945;<sub>2</sub>ß<sub>1</sub> integrin­mediated adhesion in HT­29 human colorectal cancer cells.

Kim, Jin-Eun; Lee, Sun Kyoung; Park, Junhee; Jung, Min Ju; An, So-Eun; Yang, Hye Ji; Chung, Won-Yoon

Buddlejasaponin IV induces apoptotic cell death by activating the mitochondrialdependent apoptotic pathway and reducing α₂ß₁ integrinmediated adhesion in HT29 human colorectal cancer cells.

Kim, Jin-Eun; Lee, Sun Kyoung; Park, Junhee; Jung, Min Ju; An, So-Eun; Yang, Hye Ji; Chung, Won-Yoon.

Afiliação

Kim JE; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Lee SK; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Park J; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Jung MJ; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
An SE; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Yang HJ; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.
Chung WY; Department of Oral Biology, Oral Cancer Research Institute, and BK21 FOUR Project INNODent Convergence Academy, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea.

Oncol Rep ; 49(3)2023 03.

Article em En | MEDLINE | ID: mdl-36799199

Assuntos

Neoplasias do Colo; Proteínas Proto-Oncogênicas c-akt; Humanos; Animais; Camundongos; Células HT29; Caspase 3; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Proteína X Associada a bcl-2; Apoptose; Proteína-Tirosina Quinases de Adesão Focal/metabolismo; Adesão Celular; Anoikis; Integrinas/metabolismo

Palavras-chave

Akt; a2ß1 integrin; anoikis; apoptosis; buddlejasaponin IV; cell adhesion; focal adhesion kinase; mitochondrialdependent

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Proteínas Proto-Oncogênicas c-akt Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncol Rep Assunto da revista: NEOPLASIAS Ano de publicação: 2023 Tipo de documento: Article

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