Fragment-based drug discovery supports drugging 'undruggable' protein-protein interactions.

Wang, Zhi-Zheng; Shi, Xing-Xing; Huang, Guang-Yi; Hao, Ge-Fei; Yang, Guang-Fu

Wang, Zhi-Zheng; Shi, Xing-Xing; Huang, Guang-Yi; Hao, Ge-Fei; Yang, Guang-Fu.

Afiliação

Wang ZZ; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, PR China.
Shi XX; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, PR China.
Huang GY; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, PR China.
Hao GF; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, PR China; National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of
Yang GF; National Key Laboratory of Green Pesticide, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan, 430079, PR China. Electronic address: gfyang@mail.ccnu.edu.cn.

Trends Biochem Sci ; 48(6): 539-552, 2023 06.

Article em En | MEDLINE | ID: mdl-36841635

Assuntos

Descoberta de Drogas; Ligação Proteica

Palavras-chave

PPI modulator; fragment evolution; fragment screening; hot spot; structure-based drug design

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Descoberta de Drogas Tipo de estudo: Guideline Idioma: En Revista: Trends Biochem Sci Ano de publicação: 2023 Tipo de documento: Article

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