Analysis of clinical characteristics and prognosis of 68 patients with primary pulmonary choriocarcinoma.
BMC Pulm Med
; 23(1): 75, 2023 Mar 08.
Article
em En
| MEDLINE
| ID: mdl-36890515
ABSTRACT
BACKGROUND:
Primary pulmonary choriocarcinoma (PPC) is a highly malignant intrapulmonary tumor with a notorious prognosis. Few clinical studies have been undertaken to investigate the clinical characteristics and prognosis of PPC. MATERIAL ANDMETHODS:
We systematically conducted a retrospective analysis of patients with PPC in the literature published in PubMed and CNKI databases until March 31, 2022. The primary outcome was all-cause mortality. Survival curves were depicted using the KaplanâMeier method and compared using the stratified log-rank test. A Cox proportional hazards model was used to estimate the prognostic factors.RESULTS:
A total of 68 patients were included, which consisted of 32 females and 36 males, with an average age of (44.5 ± 16.8) years old, ranging from 19 to 77 years. The clinical characteristics were mostly cough (49.2%), dyspnea (22.2%), hemoptysis (39.7%) and chest pain (39.7%). KaplanâMeier analysis showed that sex, age, hemoptysis, metastasis and treatment combining surgery with chemotherapy had a significant effect on survival. There were no effects on other outcomes. Furthermore, univariate and multivariable Cox regression analyses showed that the impact of the treatment combining surgery with chemotherapy on OS showed independent prognostic significance.CONCLUSION:
PPC is a rare disease that lacks specific clinical features. Early diagnosis with optimal management is a significant goal. Surgery followed by adjuvant chemotherapy may be the best treatment for PPC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coriocarcinoma
/
Hemoptise
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
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Pregnancy
Idioma:
En
Revista:
BMC Pulm Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China