Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models.

Liu, Xin-Mo; Xia, Shao-You; Long, Wei; Li, Hai-Jun; Yang, Gui-Qun; Sun, Wen; Li, Song-Yan; Du, Xiao-Hui

Liu, Xin-Mo; Xia, Shao-You; Long, Wei; Li, Hai-Jun; Yang, Gui-Qun; Sun, Wen; Li, Song-Yan; Du, Xiao-Hui.

Afiliação

Liu XM; Department of General Surgery, Chinese PLA General Hospital, Beijing 100039, China.
Xia SY; Medical School of Chinese PLA, Beijing 100039, China.
Long W; Department of General Surgery, Chinese PLA General Hospital, Beijing 100039, China.
Li HJ; Medical School of Chinese PLA, Beijing 100039, China.
Yang GQ; Department of Chemistry, Jacobio Pharmaceuticals, Beijing 102600, China.
Sun W; Department of Chemistry, Jacobio Pharmaceuticals, Beijing 102600, China.
Li SY; Department of Pharmacology, Jacobio Pharmaceuticals, Beijing 102600, China.
Du XH; Department of Anesthesiology, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China.

World J Gastrointest Oncol ; 15(2): 332-342, 2023 Feb 15.

Article em En | MEDLINE | ID: mdl-36908321

Palavras-chave

Bromodomain; Bromodomain and extraterminal domain inhibitor; Colorectal cancer; JAB-8263; MYC; p21

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: World J Gastrointest Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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