Subtherapeutic Exposure of Ganciclovir in Children Despite Appropriate Dosing: A Short Communication.
Ther Drug Monit
; 45(2): 269-272, 2023 04 01.
Article
em En
| MEDLINE
| ID: mdl-36920505
ABSTRACT
ABSTRACT Therapeutic drug monitoring (TDM) results for ganciclovir in 12 different treatment episodes showed large intraindividual and interindividual variabilities in the trough concentration and area under the 24-hour concentration-time curve (AUC24). Despite adequate valganciclovir dosing, subtherapeutic concentrations were found in 30% of the treatment episodes. A decrease in viral load was observed regardless of subtherapeutic exposure. These findings show the need for target concentration evaluation and assessment of the applicability of ganciclovir TDM in children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ganciclovir
/
Infecções por Citomegalovirus
Limite:
Child
/
Humans
Idioma:
En
Revista:
Ther Drug Monit
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Holanda