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HIV-1 remission and possible cure in a woman after haplo-cord blood transplant.
Hsu, Jingmei; Van Besien, Koen; Glesby, Marshall J; Pahwa, Savita; Coletti, Anne; Warshaw, Meredith G; Petz, Larry; Moore, Theodore B; Chen, Ya Hui; Pallikkuth, Suresh; Dhummakupt, Adit; Cortado, Ruth; Golner, Amanda; Bone, Frederic; Baldo, Maria; Riches, Marcie; Mellors, John W; Tobin, Nicole H; Browning, Renee; Persaud, Deborah; Bryson, Yvonne.
Afiliação
  • Hsu J; Department of Medicine, Division of Hematology & Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA. Electronic address: jingmei.hsu@nyulangone.org.
  • Van Besien K; Department of Medicine, Division of Hematology & Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA.
  • Glesby MJ; Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA.
  • Pahwa S; Department of Microbiology and Immunology, Pediatrics and Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Coletti A; Family Health International 360, Durham, NC 27761, USA.
  • Warshaw MG; Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
  • Petz L; StemCyte International Cord Blood Center, Baldwin Park, CA 91706, USA.
  • Moore TB; Department of Pediatrics, Division of Hematology& Oncology, Ronald Reagan UCLA Medical Center, Los Angeles, CA 90095, USA.
  • Chen YH; Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.
  • Pallikkuth S; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Dhummakupt A; Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.
  • Cortado R; Department of Pediatrics, Division of Infectious Diseases, Mattel Children's, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Golner A; Frontier Science & Technology Research Foundation, Inc, Amherst, NY 14226, USA.
  • Bone F; Frontier Science & Technology Research Foundation, Inc, Amherst, NY 14226, USA.
  • Baldo M; Department of Medicine, Division of Hematology & Oncology, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY 10021, USA.
  • Riches M; Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin Clinical Cancer Center, Milwaukee, WI 53226, USA.
  • Mellors JW; Department of Medicine, Division of Infectious Diseases, University of Pittsburg School of Medicine, Pittsburgh, PA 15261, USA.
  • Tobin NH; Department of Pediatrics, Division of Infectious Diseases, Mattel Children's, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Browning R; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
  • Persaud D; Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21025, USA.
  • Bryson Y; Department of Pediatrics, Division of Infectious Diseases, Mattel Children's, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell ; 186(6): 1115-1126.e8, 2023 03 16.
Article em En | MEDLINE | ID: mdl-36931242
ABSTRACT
Previously, two men were cured of HIV-1 through CCR5Δ32 homozygous (CCR5Δ32/Δ32) allogeneic adult stem cell transplant. We report the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant (cord blood cells combined with haploidentical stem cells from an adult) to treat acute myeloid leukemia (AML). Peripheral blood chimerism was 100% CCR5Δ32/Δ32 cord blood by week 14 post-transplant and persisted through 4.8 years of follow-up. Immune reconstitution was associated with (1) loss of detectable replication-competent HIV-1 reservoirs, (2) loss of HIV-1-specific immune responses, (3) in vitro resistance to X4 and R5 laboratory variants, including pre-transplant autologous latent reservoir isolates, and (4) 18 months of HIV-1 control with aviremia, off antiretroviral therapy, starting at 37 months post-transplant. CCR5Δ32/Δ32 haplo-cord transplant achieved remission and a possible HIV-1 cure for a person of diverse ancestry, living with HIV-1, who required a stem cell transplant for acute leukemia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Infecções por HIV / HIV-1 / Transplante de Células-Tronco Hematopoéticas / Transplante de Células-Tronco de Sangue do Cordão Umbilical Limite: Adult / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Infecções por HIV / HIV-1 / Transplante de Células-Tronco Hematopoéticas / Transplante de Células-Tronco de Sangue do Cordão Umbilical Limite: Adult / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2023 Tipo de documento: Article