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Economic burden and health-related quality-of-life among infants with respiratory syncytial virus infection: A multi-country prospective cohort study in Europe.
Mao, Zhuxin; Li, Xiao; Dacosta-Urbieta, Ana; Billard, Marie-Noëlle; Wildenbeest, Joanne; Korsten, Koos; Martinón-Torres, Federico; Heikkinen, Terho; Cunningham, Steve; Snape, Matthew D; Robinson, Hannah; Pollard, Andrew J; Postma, Maarten; Dervaux, Benoit; Hens, Niel; Bont, Louis; Bilcke, Joke; Beutels, Philippe.
Afiliação
  • Mao Z; Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), University of Antwerp, Belgium. Electronic address: Zhuxin.Mao@uantwerpen.be.
  • Li X; Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), University of Antwerp, Belgium.
  • Dacosta-Urbieta A; Translational Paediatrics and Infectious Diseases, Paediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain; Genetics Vaccines Infectious Diseases and Pediatrics research group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Spa
  • Billard MN; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
  • Wildenbeest J; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht, The Netherlands.
  • Korsten K; Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands; Amsterdam UMC location University of Amsterdam, Department of Medical Microbiology, Meibergdreef 9, Amsterdam, The Netherlands.
  • Martinón-Torres F; Translational Paediatrics and Infectious Diseases, Paediatrics Department, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain; Genetics Vaccines Infectious Diseases and Pediatrics research group GENVIP, Instituto de Investigación Sanitaria de Santiago (IDIS), Spa
  • Heikkinen T; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
  • Cunningham S; Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
  • Snape MD; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Pollard AJ; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Postma M; Department of Health Sciences, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands; Department of Economics, Econometrics and Finance, Faculty of Economics and Business, University of Groningen, Groningen, The Netherlands; Center of Excellence in Higher Education
  • Dervaux B; Institut Pasteur U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Univ Lille, Inserm, CHU Lille, 59000 Lille, France.
  • Hens N; Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), University of Antwerp, Belgium; Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BIOSTAT), Data Science Institute (DSI), Hasselt University, Hasselt, Belgium.
  • Bont L; Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands; The Respiratory Syncytial Virus Network (ReSViNET) Foundation, Zeist, The Netherlands.
  • Bilcke J; Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), University of Antwerp, Belgium.
  • Beutels P; Centre for Health Economics Research and Modelling Infectious Diseases (CHERMID), University of Antwerp, Belgium.
Vaccine ; 41(16): 2707-2715, 2023 04 17.
Article em En | MEDLINE | ID: mdl-36941154
ABSTRACT

BACKGROUND:

Respiratory syncytial virus (RSV) causes a considerable disease burden in young children globally, but reliable estimates of RSV-related costs and health-related quality-of-life (HRQoL) are scarce. This study aimed to evaluate the RSV-associated costs and HRQoL effects in infants and their caregivers in four European countries.

METHODS:

Healthy term-born infants were recruited at birth and actively followed up in four European countries. Symptomatic infants were systematically tested for RSV. Caregivers recorded the daily HRQoL of their child and themselves, measured by a modified EQ-5D with Visual Analogue Scale, for 14 consecutive days or until symptoms resolved. At the end of each RSV episode, caregivers reported healthcare resource use and work absenteeism. Direct medical costs per RSV episode were estimated from a healthcare payer's perspective and indirect costs were estimated from a societal perspective. Means and 95% confidence intervals (CI) of direct medical costs, total costs (direct costs + productivity loss) and quality-adjusted life-day (QALD) loss per RSV episode were estimated per RSV episode, as well as per subgroup (medical attendance, country).

RESULTS:

Our cohort of 1041 infants experienced 265 RSV episodes with a mean symptom duration of 12.5 days. The mean (95% CI) cost per RSV episode was €399.5 (242.3, 584.2) and €494.3 (317.7, 696.1) from the healthcare payer's and societal perspective, respectively. The mean QALD loss per RSV episode of 1.9 (1.7, 2.1) was independent of medical attendance (in contrast to costs, which also differed by country). Caregiver and infant HRQoL evolved similarly.

CONCLUSION:

This study fills essential gaps for future economic evaluations by prospectively estimating direct and indirect costs and HRQoL effects on healthy term infants and caregivers separately, for both medically attended (MA) and non-MA laboratory-confirmed RSV episodes. We generally observed greater HRQoL losses than in previous studies which used non-community and/or non-prospective designs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Tipo de estudo: Etiology_studies / Health_economic_evaluation / Observational_studies / Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant / Newborn País/Região como assunto: Europa Idioma: En Revista: Vaccine Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial Tipo de estudo: Etiology_studies / Health_economic_evaluation / Observational_studies / Risk_factors_studies Limite: Child / Child, preschool / Humans / Infant / Newborn País/Região como assunto: Europa Idioma: En Revista: Vaccine Ano de publicação: 2023 Tipo de documento: Article