Integration-segregation dynamics in functional networks of individuals diagnosed with schizophrenia.
Eur J Neurosci
; 57(10): 1748-1762, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36942450
ABSTRACT
Schizophrenia has been associated with dysfunction in information integration/segregation dynamics. One of the neural networks whose role has been most investigated in schizophrenia is the default mode network (DMN). In this study, we have explored the possible alteration of integration and segregation dynamics in individuals diagnosed with schizophrenia with respect to healthy controls, based on the study of the topological properties of the graphs derived from the functional connectivity between the nodes of the DMN in the resting state. Our results indicate that the patients show a diminution of the modularity of the DMN and a higher global efficiency, in sparse graphs. Our data emphasise the interest in studying temporal changes in network measures and are compatible with the hypothesis of randomization of functional networks in schizophrenia.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Eur J Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha