Senescent Secretome of Blind Mole Rat <i>Spalax</i> Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response.

Odeh, Amani; Eddini, Hossam; Shawasha, Lujain; Chaban, Anastasia; Avivi, Aaron; Shams, Imad; Manov, Irena

Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response.

Odeh, Amani; Eddini, Hossam; Shawasha, Lujain; Chaban, Anastasia; Avivi, Aaron; Shams, Imad; Manov, Irena.

Afiliação

Odeh A; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Eddini H; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Shawasha L; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Chaban A; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Avivi A; Institute of Evolution, University of Haifa, 199 Aba Khoushy Avenue, Haifa 3498838, Israel.
Shams I; Department of Evolutionary and Environmental Biology, Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Avenue, Mount Carmel, Haifa 3498838, Israel.
Manov I; Institute of Evolution, University of Haifa, 199 Aba Khoushy Avenue, Haifa 3498838, Israel.

Int J Mol Sci ; 24(6)2023 Mar 07.

Article em En | MEDLINE | ID: mdl-36982207

Assuntos

Neoplasias da Mama; Spalax; Animais; Humanos; Feminino; Ratos-Toupeira; Neoplasias da Mama/tratamento farmacológico; Secretoma; Senescência Celular; Microambiente Tumoral

Palavras-chave

Spalax fibroblasts; breast cancer cells; interleukin 1 alpha (IL1α); nuclear factor κB (NF-κB); paracrine senescence; senescence-associated secretory phenotype (SASP)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Spalax Limite: Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Israel

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